Face skin hyperpigmentation during pegylated interferon and ribavirin therapy.

Cutaneous hyperpigmentation may be caused by a number of diseases, such as Addison’s disease, scleroderma, haemochromatosis, Peutz-Jeghers syndrome, lichen planus, and adverse reactions to some medications such as oral contraceptives, cyclophosphamide, chloroquine, minocycline, bleomycin, ketoconazole and methyldopa (1). Hyperpigmentation of the tongue, face and body skin is a rare adverse effect of interferon (IFN) and ribavirin combination therapy.